PIER
 
Progress In Electromagnetics Research
ISSN: 1070-4698, E-ISSN: 1559-8985
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A STUDY ON THE BIOCOMPATIBILITY OF SURFACE-MODIFIED Au/Ag ALLOYED NANOBOX PARTICLES IN ZEBRAFISH IN TERMS OF MORTALITY RATE, HATCH RATE AND IMAGING OF PARTICLE DISTRIBUTION BEHAVIOR

By K. Li, X. Zhao, Y. Zhai, G. Chen, E.-H. Lee, and S. He

Full Article PDF (406 KB)

Abstract:
We report, for the first time, a study on the biocompatibility of the poly(ethylene glycol)-thiol (PEG)-coated Au/Ag alloyed nanobox (PC-ANB) particles in zebrafish. We measured the mortality rate and the hatch rate of the zebrafish embryos injected with the PC-ANB particles and observed the distribution of the PC-ANB particles in the zebrafish embryos at different stages of growth development. The results show that the PC-ANB particles have negligible toxicity to the zebrafish embryos even at extra-high concentration (1.2 mg ml-1), while uncoated Ag nanoparticles, used in the form of nanospheres or nanoplates, were found to cause embryo deformation or even death. Additionally, we have investigated the distribution of the PC-ANB particles within the zebrafish in the interest of studying their behavior in the zebrafish using imaging. For this, we used the three-photon luminescence imaging technique and it has been found that the PC-ANB particles mainly assemble in the backside muscle tissues of the zebrafish, suggesting that the PC-ANB particles are mostly metabolized out after about 96 hours of growth development.

Citation:
K. Li, X. Zhao, Y. Zhai, G. Chen, E.-H. Lee, and S. He, "A Study on the Biocompatibility of Surface-Modified Au/Ag Alloyed Nanobox Particles in Zebrafish in Terms of Mortality Rate, Hatch Rate and Imaging of Particle Distribution Behavior," Progress In Electromagnetics Research, Vol. 150, 89-96, 2015.
doi:10.2528/PIER14092602
http://www.jpier.org/PIER/pier.php?paper=14092602

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