Progress In Electromagnetics Research M
ISSN: 1937-8726
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By Z. Chen, H. Ye, H. Xu, S. An, A. Jin, C. Zhou, and S. Yang

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The beneficial effects of chronic/repeated magnetic stimulation on humans have been examined in previous studies. Although pain relief effects have been reported several weeks after magnetic treatment, no report is available regarding the prompt effect of magnetic stimulations. In this study, a novel apparatus was developed to generate time-varying magnetic fields with rotating magnets. Adult, conscious rats were exposed to the rotating magnets in a posture in which their spines were parallel to the induced electric current. The magnetic field suppressed the paw withdrawal reflex in the anesthetized rats, and the suppression effect disappeared 5 minutes after magnets stopped rotating. The tail flick (TF) latency and mechanic withdrawal thresholds (MWT) of the rats were significantly increased by the rotating magnets; the increases positively correlated with the velocity and period of the magnet rotating. These analgesia effects recovered to the baseline level 30 minutes after magnets stopped rotating. A biophysics model was proposed to qualitatively understand the mechanism of pain inhibition by the rotating field. The prompt analgesia effect of the rotating magnets and its rapid recovery encourage the application of this technique as a promising new analgesia and anesthesia method.

Z. Chen, H. Ye, H. Xu, S. An, A. Jin, C. Zhou, and S. Yang, "Rotating Magnets Produce a Prompt Analgesia Effect in Rats," Progress In Electromagnetics Research M, Vol. 27, 203-217, 2012.

1. Cameron, T., "Safety and efficacy of spinal cord stimulation for the treatment of chronic pain: A 20-year literature review," Journal of Neurosurgery, 3 Suppl. Spine, Vol. 100, 254-267, 2004.

2. Coots, A., R. Shi, and A. D. Rosen, "Effect of a 0.5-T static magnetic field on conduction in guinea pig spinal cord," Journal of the Neurological Sciences, Vol. 222, No. 1-2, 55-57, 2004.

3. Kumar, K. , et al., "Complications of spinal cord stimulation suggestions to improve outcome, and financial impact," Journal of Neurosurgery, Vol. 5, No. 3, 191-203, Spine, 2006.

4. Rosenow, J. M., et al., "Failure modes of spinal cord stimulation hardware," Journal of Neurosurgery, Vol. 5, No. 3, 183-190, Spine, 2006.

5. De Leon-Casasola, O. A., "Spinal cord and peripheral nerve stimulation techniques for neuropathic pain," Journal of Pain and Symptom Management, Vol. 38, 28-38, 2 Suppl., 2009.

6. Kovacs-Balint, Z., et al., "Exposure to an inhomogeneous static magnetic field increases thermal pain threshold in healthy human volunteers," Bioelectromagnetics, Vol. 32, No. 2, 131-139, 2011.

7. Laszlo, J. and N. Pivec, "Effect of inhomogeneous static magnetic field on dental pain in humans," The Clinical Journal of Pain, Vol. 26, No. 1, 49-55, 2010.

8. Thomas, A. W., et al., "A randomized, double-blind, placebo-controlled clinical trial using a low-frequency magnetic field in the treatment of musculoskeletal chronic pain," Pain Research & Management: The Journal of the Canadian Pain Society, Vol. 12, No. 4, 249-258, 2007.

9. Eccles, N. K., "A critical review of randomized controlled trials of static magnets for pain relief," Journal of Alternative and Complementary Medicine, Vol. 11, No. 3, 495-509, 2005.

10. Hong, C. Z., et al., "Magnetic necklace: Its therapeutic effectiveness on neck and shoulder pain," Archives of Physical Medicine and Rehabilitation, Vol. 63, No. 10, 462-466, 1982.

11. Salomonowitz, G. , M. Friedrich, and B. J. Guntert, "Medical relevance of magnetic fields in pain therapy," Schmerz, Vol. 25, No. 2, 157-160, 162-165, 2011.

12. Khoromi, S., et al., "Low intensity permanent magnets in the treatment of chronic lumbar radicular pain," Journal of Pain and Symptom Management, Vol. 34, No. 4, 434-445, 2007.

13. Thuile, C. and M. Walzl, "Evaluation of electromagnetic fields in the treatment of pain in patients with lumbar radiculopathy or the whiplash syndrome," NeuroRehabilitation, Vol. 17, No. 1, 63-67, 2002.

14. Saunders, R., "Static magnetic fields: Animal studies," Progress in Biophysics and Molecular Biology, Vol. 87, No. 2-3, 225-239, 2005.

15. Wikswo, J. P. , J. P. Barach, and , "An estimate of the steady magnetic field strength required to influence nerve conduction," EEE Transactions on Bio-medical Engineering, Vol. 27, No. 12, 722-723, 1980.

16. Lefaucheur, J. P., X. Drouot, and J. P. Nguyen, "Interventional neurophysiology for pain control: Duration of pain relief following repetitive transcranial magnetic stimulation of the motor cortex," Neurophysiologie Clinique, Vol. 31, No. 4, 247-252, 2001.

17. Sampson, S. M., et al., "The use of slow-frequency prefrontal repetitive transcranial magnetic stimulation in refractory neuro-pathic pain," The Journal of ECT, Vol. 27, No. 1, 33-37, 2011.

18. Vavken, P., et al., "Effectiveness of pulsed electromagnetic field therapy in the management of osteoarthritis of the knee: A meta-analysis of randomized controlled trials," Journal of Rehabilitation Medicine: O┬▒cial Journal of the UEMS European Board of Physical and Rehabilitation Medicine, Vol. 41, No. 6, 406-411, 2009.

19. Shupak, N. M., et al., "Exposure to a specific pulsed low-frequency magnetic field: A double-blind placebo-controlled study of effects on pain ratings in rheumatoid arthritis and fibromyalgia patients," Pain Research & Management: The Journal of the Canadian Pain Society, Vol. 11, No. 2, 85-90, 2006.

20. Kaneko, M., et al., "Synergistic antinociceptive interaction after epidural coadministration of morphine and lidocaine in rats," Anesthesiology, Vol. 80, No. 1, 137-150, 1994.

21. Yamamori, Y., et al., "Antinociceptive effects of ONO-9902, an enkephalinase inhibitor, after visceral stress condition in rats," Canadian Journal of Anaesthesia, Vol. 43, No. 11, 1175-1179, 1996.

22. Roth, B. J. and P. J. Basser, "A model of the stimulation of a nerve fiber by electromagnetic induction," IEEE Transactions on Bio-medical Engineering, Vol. 37, No. 6, 588-597, 1990.

23. Ye, H., et al., "Transmembrane potential generated by a magnetically induced transverse electric field in a cylindrical axonal model," Medical & Biological Engineering & Computing, Vol. 49, No. 1, 107-119, 2011.

24. Rattay, F., "Analysis of models for external stimulation of axons," IEEE Transactions on Bio-medical Engineering, Vol. 33, No. 10, 974-977, 1986.

25. Bhadra, N. , et al., "Simulation of high-frequency sinusoidal Simulation of high-frequency sinusoidal," Journal of Computational Neuroscience, Vol. 22, No. 3, 313-326, 2007.

26. Kilgore, K. L. and N. Bhadra, "High frequency mammalian nerve conduction block: Simulations and experiments," Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vol. 1, 4971-4974, 2006.

27. Reato, D., et al., "Low-intensity electrical stimulation affects network dynamics by modulating population rate and spike timing," The Journal of Neuroscience: The official journal of the Society for Neuroscience, Vol. 30, No. 45, 15067-15079, 2010.

28. Gluckman, B. J., et al., "Electric field suppression of epileptiform activity in hippocampal slices," Journal of Neurophysiology, Vol. 76, No. 6, 4202-4205, 1996.

29. Liu, H., et al., "The role of slow potassium current in nerve conduction block induced by high-frequency biphasic electrical current," IEEE Transactions on Bio-medical Engineering, Vol. 56, No. 1, 137-146, 2009.

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