Vol. 27
Latest Volume
All Volumes
PIERM 114 [2022] PIERM 113 [2022] PIERM 112 [2022] PIERM 111 [2022] PIERM 110 [2022] PIERM 109 [2022] PIERM 108 [2022] PIERM 107 [2022] PIERM 106 [2021] PIERM 105 [2021] PIERM 104 [2021] PIERM 103 [2021] PIERM 102 [2021] PIERM 101 [2021] PIERM 100 [2021] PIERM 99 [2021] PIERM 98 [2020] PIERM 97 [2020] PIERM 96 [2020] PIERM 95 [2020] PIERM 94 [2020] PIERM 93 [2020] PIERM 92 [2020] PIERM 91 [2020] PIERM 90 [2020] PIERM 89 [2020] PIERM 88 [2020] PIERM 87 [2019] PIERM 86 [2019] PIERM 85 [2019] PIERM 84 [2019] PIERM 83 [2019] PIERM 82 [2019] PIERM 81 [2019] PIERM 80 [2019] PIERM 79 [2019] PIERM 78 [2019] PIERM 77 [2019] PIERM 76 [2018] PIERM 75 [2018] PIERM 74 [2018] PIERM 73 [2018] PIERM 72 [2018] PIERM 71 [2018] PIERM 70 [2018] PIERM 69 [2018] PIERM 68 [2018] PIERM 67 [2018] PIERM 66 [2018] PIERM 65 [2018] PIERM 64 [2018] PIERM 63 [2018] PIERM 62 [2017] PIERM 61 [2017] PIERM 60 [2017] PIERM 59 [2017] PIERM 58 [2017] PIERM 57 [2017] PIERM 56 [2017] PIERM 55 [2017] PIERM 54 [2017] PIERM 53 [2017] PIERM 52 [2016] PIERM 51 [2016] PIERM 50 [2016] PIERM 49 [2016] PIERM 48 [2016] PIERM 47 [2016] PIERM 46 [2016] PIERM 45 [2016] PIERM 44 [2015] PIERM 43 [2015] PIERM 42 [2015] PIERM 41 [2015] PIERM 40 [2014] PIERM 39 [2014] PIERM 38 [2014] PIERM 37 [2014] PIERM 36 [2014] PIERM 35 [2014] PIERM 34 [2014] PIERM 33 [2013] PIERM 32 [2013] PIERM 31 [2013] PIERM 30 [2013] PIERM 29 [2013] PIERM 28 [2013] PIERM 27 [2012] PIERM 26 [2012] PIERM 25 [2012] PIERM 24 [2012] PIERM 23 [2012] PIERM 22 [2012] PIERM 21 [2011] PIERM 20 [2011] PIERM 19 [2011] PIERM 18 [2011] PIERM 17 [2011] PIERM 16 [2011] PIERM 14 [2010] PIERM 13 [2010] PIERM 12 [2010] PIERM 11 [2010] PIERM 10 [2009] PIERM 9 [2009] PIERM 8 [2009] PIERM 7 [2009] PIERM 6 [2009] PIERM 5 [2008] PIERM 4 [2008] PIERM 3 [2008] PIERM 2 [2008] PIERM 1 [2008]
2012-11-27
Rotating Magnets Produce a Prompt Analgesia Effect in Rats
By
Progress In Electromagnetics Research M, Vol. 27, 203-217, 2012
Abstract
The beneficial effects of chronic/repeated magnetic stimulation on humans have been examined in previous studies. Although pain relief effects have been reported several weeks after magnetic treatment, no report is available regarding the prompt effect of magnetic stimulations. In this study, a novel apparatus was developed to generate time-varying magnetic fields with rotating magnets. Adult, conscious rats were exposed to the rotating magnets in a posture in which their spines were parallel to the induced electric current. The magnetic field suppressed the paw withdrawal reflex in the anesthetized rats, and the suppression effect disappeared 5 minutes after magnets stopped rotating. The tail flick (TF) latency and mechanic withdrawal thresholds (MWT) of the rats were significantly increased by the rotating magnets; the increases positively correlated with the velocity and period of the magnet rotating. These analgesia effects recovered to the baseline level 30 minutes after magnets stopped rotating. A biophysics model was proposed to qualitatively understand the mechanism of pain inhibition by the rotating field. The prompt analgesia effect of the rotating magnets and its rapid recovery encourage the application of this technique as a promising new analgesia and anesthesia method.
Citation
Zhong Chen Hui Ye Haiyun Xu Shukang An Anmin Jin Chusong Zhou Shaoan Yang , "Rotating Magnets Produce a Prompt Analgesia Effect in Rats," Progress In Electromagnetics Research M, Vol. 27, 203-217, 2012.
doi:10.2528/PIERM12100915
http://www.jpier.org/PIERM/pier.php?paper=12100915
References

1. Cameron, T., "Safety and efficacy of spinal cord stimulation for the treatment of chronic pain: A 20-year literature review," Journal of Neurosurgery, 3 Suppl. Spine, Vol. 100, 254-267, 2004.

2. Coots, A., R. Shi, and A. D. Rosen, "Effect of a 0.5-T static magnetic field on conduction in guinea pig spinal cord," Journal of the Neurological Sciences, Vol. 222, No. 1-2, 55-57, 2004.
doi:10.1016/j.jns.2004.04.010

3. Kumar, K. , et al., "Complications of spinal cord stimulation suggestions to improve outcome, and financial impact," Journal of Neurosurgery, Vol. 5, No. 3, 191-203, Spine, 2006.

4. Rosenow, J. M., et al., "Failure modes of spinal cord stimulation hardware," Journal of Neurosurgery, Vol. 5, No. 3, 183-190, Spine, 2006.

5. De Leon-Casasola, O. A., "Spinal cord and peripheral nerve stimulation techniques for neuropathic pain," Journal of Pain and Symptom Management, Vol. 38, 28-38, 2 Suppl., 2009.

6. Kovacs-Balint, Z., et al., "Exposure to an inhomogeneous static magnetic field increases thermal pain threshold in healthy human volunteers," Bioelectromagnetics, Vol. 32, No. 2, 131-139, 2011.
doi:10.1002/bem.20622

7. Laszlo, J. and N. Pivec, "Effect of inhomogeneous static magnetic field on dental pain in humans," The Clinical Journal of Pain, Vol. 26, No. 1, 49-55, 2010.
doi:10.1097/AJP.0b013e3181b511d5

8. Thomas, A. W., et al., "A randomized, double-blind, placebo-controlled clinical trial using a low-frequency magnetic field in the treatment of musculoskeletal chronic pain," Pain Research & Management: The Journal of the Canadian Pain Society, Vol. 12, No. 4, 249-258, 2007.

9. Eccles, N. K., "A critical review of randomized controlled trials of static magnets for pain relief," Journal of Alternative and Complementary Medicine, Vol. 11, No. 3, 495-509, 2005.
doi:10.1089/acm.2005.11.495

10. Hong, C. Z., et al., "Magnetic necklace: Its therapeutic effectiveness on neck and shoulder pain," Archives of Physical Medicine and Rehabilitation, Vol. 63, No. 10, 462-466, 1982.

11. Salomonowitz, G. , M. Friedrich, and B. J. Guntert, "Medical relevance of magnetic fields in pain therapy," Schmerz, Vol. 25, No. 2, 157-160, 162-165, 2011.
doi:10.1007/s00482-010-1005-0

12. Khoromi, S., et al., "Low intensity permanent magnets in the treatment of chronic lumbar radicular pain," Journal of Pain and Symptom Management, Vol. 34, No. 4, 434-445, 2007.
doi:10.1016/j.jpainsymman.2006.12.008

13. Thuile, C. and M. Walzl, "Evaluation of electromagnetic fields in the treatment of pain in patients with lumbar radiculopathy or the whiplash syndrome," NeuroRehabilitation, Vol. 17, No. 1, 63-67, 2002.

14. Saunders, R., "Static magnetic fields: Animal studies," Progress in Biophysics and Molecular Biology, Vol. 87, No. 2-3, 225-239, 2005.
doi:10.1016/j.pbiomolbio.2004.09.001

15. Wikswo, J. P. , J. P. Barach, and , "An estimate of the steady magnetic field strength required to influence nerve conduction," EEE Transactions on Bio-medical Engineering, Vol. 27, No. 12, 722-723, 1980.
doi:10.1109/TBME.1980.326598

16. Lefaucheur, J. P., X. Drouot, and J. P. Nguyen, "Interventional neurophysiology for pain control: Duration of pain relief following repetitive transcranial magnetic stimulation of the motor cortex," Neurophysiologie Clinique, Vol. 31, No. 4, 247-252, 2001.
doi:10.1016/S0987-7053(01)00260-X

17. Sampson, S. M., et al., "The use of slow-frequency prefrontal repetitive transcranial magnetic stimulation in refractory neuro-pathic pain," The Journal of ECT, Vol. 27, No. 1, 33-37, 2011.
doi:10.1097/YCT.0b013e31820c6270

18. Vavken, P., et al., "Effectiveness of pulsed electromagnetic field therapy in the management of osteoarthritis of the knee: A meta-analysis of randomized controlled trials," Journal of Rehabilitation Medicine: O±cial Journal of the UEMS European Board of Physical and Rehabilitation Medicine, Vol. 41, No. 6, 406-411, 2009.
doi:10.2340/16501977-0374

19. Shupak, N. M., et al., "Exposure to a specific pulsed low-frequency magnetic field: A double-blind placebo-controlled study of effects on pain ratings in rheumatoid arthritis and fibromyalgia patients," Pain Research & Management: The Journal of the Canadian Pain Society, Vol. 11, No. 2, 85-90, 2006.

20. Kaneko, M., et al., "Synergistic antinociceptive interaction after epidural coadministration of morphine and lidocaine in rats," Anesthesiology, Vol. 80, No. 1, 137-150, 1994.
doi:10.1097/00000542-199401000-00021

21. Yamamori, Y., et al., "Antinociceptive effects of ONO-9902, an enkephalinase inhibitor, after visceral stress condition in rats," Canadian Journal of Anaesthesia, Vol. 43, No. 11, 1175-1179, 1996.
doi:10.1007/BF03011848

22. Roth, B. J. and P. J. Basser, "A model of the stimulation of a nerve fiber by electromagnetic induction," IEEE Transactions on Bio-medical Engineering, Vol. 37, No. 6, 588-597, 1990.
doi:10.1109/10.55662

23. Ye, H., et al., "Transmembrane potential generated by a magnetically induced transverse electric field in a cylindrical axonal model," Medical & Biological Engineering & Computing, Vol. 49, No. 1, 107-119, 2011.
doi:10.1007/s11517-010-0704-0

24. Rattay, F., "Analysis of models for external stimulation of axons," IEEE Transactions on Bio-medical Engineering, Vol. 33, No. 10, 974-977, 1986.
doi:10.1109/TBME.1986.325670

25. Bhadra, N. , et al., "Simulation of high-frequency sinusoidal Simulation of high-frequency sinusoidal," Journal of Computational Neuroscience, Vol. 22, No. 3, 313-326, 2007.
doi:10.1007/s10827-006-0015-5

26. Kilgore, K. L. and N. Bhadra, "High frequency mammalian nerve conduction block: Simulations and experiments," Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vol. 1, 4971-4974, 2006.

27. Reato, D., et al., "Low-intensity electrical stimulation affects network dynamics by modulating population rate and spike timing," The Journal of Neuroscience: The official journal of the Society for Neuroscience, Vol. 30, No. 45, 15067-15079, 2010.
doi:10.1523/JNEUROSCI.2059-10.2010

28. Gluckman, B. J., et al., "Electric field suppression of epileptiform activity in hippocampal slices," Journal of Neurophysiology, Vol. 76, No. 6, 4202-4205, 1996.

29. Liu, H., et al., "The role of slow potassium current in nerve conduction block induced by high-frequency biphasic electrical current," IEEE Transactions on Bio-medical Engineering, Vol. 56, No. 1, 137-146, 2009.
doi:10.1109/TBME.2008.2006013