Microwave induced thermo-acoustic tomography (MITAT) has become a keen research topic in recent years due to its great potential in early breast cancer detection. A secure and accurate MITAT system has been established. Some experiments have been made to demonstrate the performance of the MITAT system. Based on an experiment using phantom, some quantitative features of the system have been obtained. Some imaging experiments with real human breast cancer tissues are performed to demonstrate its effectiveness and the potential in clinical diagnosis. Images with both high contrast and fine spatial resolution are achieved by using time reversal mirror (TRM) technique in the imaging processing. Moreover, comparisons between the MITAT system result and an ultrasound imaging system result are made. From the comparison, the MITAT system shows its advantages of better contrast over the ultrasound imaging system. The system and the experiments in this paper verify the mechanism of MITAT for breast cancer detection and provide a prototype basis for clinical practice.
2. Geng, K. and L. V. Wang, "Scanning microwave-induced thermo-acoustic tomography: Signal, resolution, and contrast," Med. Phys., Vol. 28, No. 1, 4-10, 2001.
3. Geng, K. and L. V. Wang, "Scanning thermoacoustic tomography in biological tissue," Med. Phys., Vol. 27, No. 5, 1195-1202, 2000.
4. Nie, L. M., D. Xing, D. W. Yang, L. M. Zeng, and Q. Zhou, "Detection of foreign body using fast thermo-acoustic tomography with a multi-element linear transducer array," Appl. Phys. Lett., Vol. 90, 174109-174111, 2007.
5. Nie, L. M., D. Xing, Q. Zhou, D. W. Yang, and H. Guo, "Microwave-induced thermoacoutic scanning CT for high-contrast and noninvasive breast cancer imaging," Med. Phys., Vol. 35, No. 9, 4026-4032, 2008.
6. Zhu, G. K. and M. Popovic, "Comparison of radar and thermoacoustic technique in microwave breast imaging," Progress In Electromagnetics Research B, Vol. 35, 1-14, 2011.
7. Catapano, I., L. Di Donato, L. Crocco, O. M. Bucdi, A. F. Morabito, T. Isernia, and R. Massa, "On quantitative microwave tomography of female breast," Progress In Electromagnetics Research, Vol. 97, 75-93, 2009.
8. Lazebnik, M., "A large-scale study of the ultrawideband microwave dielectric properties of normal, benign and malignant breast tissues obtained from cancer surgeries," Phys. Med. Biol., Vol. 52, 6093-6115, 2007.
9. Geng, K., B. D. Fornage, X. Jin, M. Xu, K. K. Hunt, and L. V. Wang, "Thermoacoustic and photoacoustic tomography of thick biological tissues toward breast imaging," Technol. Cancer Res. Treat., Vol. 4, 1-7, 2005.
10. Yan, W., J.-D. Xu, N.-J. Li, and W.-X Tan, "A novel fast near-field electromagnetic imaging method for full rotation problem," Progress In Electromagnetics Research, Vol. 120, 387401, 2011.
11. Qi, Y. L., W. Tan, Y. Wang, W. Hong, and Y. Wu, "3D bistatic Omega-K imaing algorithm for near range microwave imaging system with bistatic planar scanning geometry," Progress In Electromagnetics Research, Vol. 121, 409-431, 2011.
12. Kellnberger, S., A. Hajiaboli, D. Razansky, and V. Ntziachristos, "Near-field theroacoustic tomography of small animals," Phys. Med. Biol., Vol. 56, 3433-3444, 2011.
13. Razansky, D., S. Kellnberger, and V. Ntziachristos, "Near-field radiofrequency thermo-acoustic tomography with impulse excitation," Med. Phys., Vol. 37, No. 9, 4602-4607, 2010.
14. Xie, Y., B. Guo, and J. Li, "Adaptive and robust methods of reconstruction (ARMOR) for thermo-acoustic tomography," IEEE Trans. Biomed. Eng., Vol. 55, 2741-2752, 2008.
15. Chen, G. P., Z. Q. Zhao, Z. P. Nie, and Q. H. Liu, "Computational tudy of time reversal mirror technique for microwave-induced thermo-acoustic tomography," Journal of Electromagnetic Waves and Applications, Vol. 22, No. 16, 2191-2204, 2008.
16. Chen, G. P., W. B. Yu, Z. Q. Zhao, Z. P. Nie, and Q. H. Liu, "The prototype of microwave-induced thermo-acoustic tomography imaging by time reversal mirror," Journal of Electromagnetic Waves and Applications, Vol. 22, No. 11-22, 1565-1574, 2008.
17. Chen, G. P., Z. Q. Zhao, W. J. Zheng, Z. Nie, and Q. H. Liu, "Application of time reversal mirror technique in microwave-induced thermo-acoustic tomography system," Science in China Series E: Technological Science, Vol. 52, No. 7, 2087-2095, 2009.
18. Treeby, B. E. and B. T. Cox, "K-wave: MATLAB toolbox for the simulation and reconstruction of photo-acoustic wave fields," Journal of Biomedical Optics, Vol. 15, No. 2, 021314, 2010.
19. Xu, Y. and L. V. Wang, "Time reversal and its application to tomography with diffracting sources," Phys. Rev. Lett., Vol. 92, No. 3, 1-4, 2004.
20. Fink, M. and C. Prada, "Acoustic time reversal mirror," Inv. Probl., Vol. 17, No. 1, 1-38, 2001.
21. D'Souza, W. D., et al., "Tissue mimicking materials for a multi-imaging modality prostate phantom," Med. Phys., Vol. 28, No. 4, 688-700, 2001.
22. Bauer, D., X. Wang, J. Vollin, H. Xin, and R. Witte, "Spectroscopic thermoacoustic imaging of water and fat composition," Appl. Phys. Lett., Vol. 101, 033705, 2012.
23. Blomgren, P., G. Papanicolaou, and H. Zhao, "Super-resolution in time-reversal acoustics," Journal of the Acoustical Society of America, Vol. 111, 230-248, 2002.
24. Halter, R. J., et al., "The Correlation of in vivo and ex vivo tissue dielectric properties to validate electromagnetic breast imaging: Initial clinical experience," Physiol. Meas., Vol. 30, No. 6, 121-136, 2009.