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Progress In Electromagnetics Research | ISSN: 1070-4698, E-ISSN: 1559-8985 |
Home > Vol. 99 > pp. 355-382
CHITOSAN SPHEROIDS WITH MICROWAVE MODULATED DRUG RELEASEBy Z. Zabliza and T. W. WongAbstract: The interplay effects of matrix formulations with microwave on drug release were investigated using an agglomerate system. Chitosan spheroids were formulated with stearic acid and/or sodium chloride by extrusion-spheronization technique, and chlorpheniramine maleate as water-soluble model drug. The spheroids were treated by microwave at 80 W for 5 to 40 min. The profiles of drug dissolution, drug content, drug-polymer interaction, polymer-polymer interaction, sodium leaching, matrix morphology and integrity were determined. Unlike chitosan matrix prepared by ionotropic gelation method, the retardation of drug release from chitosan spheroids by microwave required a more complex formulation containing both stearic acid and sodium chloride unless a high stearic acid fraction was used. These spheroids demonstrated a high resistance to disintegration during dissolution owing to salt-induced bridging by sodium chloride. In response to microwave, sodium chloride aided stearic acid spread and effected domain interaction via C=O moiety over a matrix with reduced specific surface area thereby reducing drug dissolution. The drug release of spheroids can be retarded by microwave through promoting the layering of hydrophobic stearic acid in a matrix structure sustained by sodium chloride.
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2. Wong, T.-W., A. Iskhandar, M. Kamal, S.-J. Jumi, N.-H. Kamarudin, N.-Z. Mohamad Zin, and N.-H. Mohd Salleh, "Effects of microwave on water and its influence on drug dissolution," Progress In Electromagnetics Research C, Vol. 11, 121-136, 2009.
3. Vandelli, M.-A., M. Romagnoli, A. Monti, M. Gozzi, P. Guerra, F. Rivasi, and F. Forni, "Microwave-treated gelatin microspheresv as drug delivery system," J. Controlled Release, Vol. 96, 67-84, 2004. 4. Nurjaya, S. and T.-W. Wong, "Effects of microwave on drug release properties of matrices of pectin," Carbohydr. Polym., Vol. 62, 245-257, 2005. 5. Wong, T.-W., A.-W. Selasiah, and A. Yolande, "Effects of microwave on drug release property of poly (methyl-vinlyether-co-maleic acid) matrix," Drug Dev. Ind. Pharm., Vol. 33, 737-746, 2007. 6. Wong, T.-W., A.-W. Selasiah, and Y. Anthony, "Drug release responses of zinc ion crosslinked poly (methyl vinyl ether-co-maleic acid) matrix towards microwave," Int. J. Pharm., Vol. 357, 154-163, 2008. 7. Wong, T.-W. and S. Nurjaya, "Drug release property of chitosan-pectinate beads and its changes under the influence of microwave," Eur. J. Pharm. Biopharm., Vol. 69, 176-188, 2008. 8. Wong, T.-W., "Use of microwave in processing of drug delivery systems," Curr. Drug Deliv., Vol. 5, 77-84, 2008. 9. Gandhi, R., C.-L. Kaul, and R. Panchagnula, "Extrusion and spheronization in the development of oral controlled-release dosage forms," Pharm. Sci. Tech. Today, Vol. 2, 160-170, 1999. 10. Chopra, R., G. Alderborn, F. Podczeck, and J.-M. Newton, "The influence of pellet shape and surface properties on the drug release from uncoated and coated pellets," Int. J. Pharm., Vol. 239, 171-178, 2002. 11. Sousa, J.-J., A. Sousa, M.-J. Moura, F. Podczeck, and J.-M. Newton, "The influence of core materials and film coating on the drug release from coated pellets," Int. J. Pharm., Vol. 233, 111-122, 2002. 12. Zheng, W., D. Sauer, and J.-W. McGinity, "Influence of hydrox-yethylcellulose on the drug release properties of theophylline pellets coated with EudragitR RS 30 D," Eur. J. Pharm. Biopharm., Vol. 59, 147-154, 2005. 13. Sriamornsak, P. and R.-A. Kennedy, "Effect of drug solubility on release behavior of calcium polysaccharide gel-coated pellets," Eur. J. Pharm. Sci., Vol. 32, 231-239, 2007. 14. Vervaet, C., L. Baert, and J.-P. Remon, "Extrusion-spheronization: A literature review," Int. J. Pharm., Vol. 116, 131-146, 1995. |