Progress In Electromagnetics Research
ISSN: 1070-4698, E-ISSN: 1559-8985
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By D. Vrba, D. B. Rodrigues, J. Vrba (Jr.), and P. R. Stauffer

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Current microwave hyperthermia applicators are not well suited for uniform heating of large tissue regions. The objective of this research is to identify an optimal microwave antenna array for clinical use in hyperthermia treatment of cancer. For this aim we present a novel 434 MHz applicator design based on a metamaterial zeroth order mode resonator, which is used to build larger array configurations. These applicators are designed to effectively heat large areas extending deep below the body surface and in this work they are characterized with numerical simulations in ahomogenous muscle tissue model. Their performance is evaluated using three metrics: radiation pattern-based Effective Field Size (EFS), temperature distribution-based Therapeutic Thermal Area (TTA), and Therapeutic Thermal Volume (TTV) reaching 41-45°C. For 2×2 and 2×3 array configurations, the EFS reaching > 25% of maximum SAR in the 3.5 cm deep plane is 100% and 91% of the array aperture area, respectively. The corresponding TTA for these arrays is 95% and 86%, respectively; and the TTV attaining > 41°C is over 85% of the aperture area toa depth of over 3 cm in muscle, using either array configuration. With theoretical heating performance exceeding that of existing applicators, these new metamaterial zero order resonator arrays show promise for future applications in large area superficial hyperthermia.

D. Vrba, D. B. Rodrigues, J. Vrba (Jr.), and P. R. Stauffer, "Metamaterial antenna arrays for improved uniformity of microwave hyperthermia treatments," Progress In Electromagnetics Research, Vol. 156, 1-12, 2016.

1. Caloz, C. and T. Itoh, Electromagnetic Metamaterials: Transmission Line Theory and Microwave Applications: The Engineering Approach, John Wiley & Sons, New Jersey, 2006.

2. Cihoric, N., A. Tsikkinis, G. van Rhoon, H. Crezee, D. M. Aebersold, S. Bodis, M. Beck, J. Nadobny, V. Budach, P. Wust, and P. Ghadjar, "Hyperthermia-related clinical trials on cancer treatment within the Clinical Trials. gov registry," International Journal of Hyperthermia, Vol. 31, No. 6, 609-614, May 2015.

3. Dewhirst, M. W., Z. Vujaskovic, E. Jones, and D. Thrallv, "Re-setting the biologic rationale for thermal therapy," International Journal of Hyperthermia, Vol. 21, No. 8, 779-790, Dec. 2005.

4. Sneed, P. K., P. R. Stauffer, G. Li, X. Sun, and R. Myerson, "Hyperthermia," Textbook of Radiation Oncology, 3rd Edition, T. Phillips, R. Hoppe, and M. Roach, eds., 1564-1593, Elsevier Saunders Co, Philadelphia, 2010.

5. Paulides, M. M., P. R. Stauffer, E. Neufeld, P. F. Maccarini, A. Kyriakou, R. A. Canters, C. J. Diederich, J. F. Bakker, and G. C. van Rhoon, "Simulation techniques in hyperthermia treatment planning," International Journal of Hyperthermia, Vol. 29, No. 4, 346-357, Jun. 2013.

6. Veselago, V., "The electrodynamics of substances with simultaneously negative values of ε and μ," Sov. Phys. Usp., Vol. 10, No. 4, 509-514, 1968 (Russian text 1967).

7. Shelby, R. A., D. R. Smith, and S. Schultz, "Experimental veri cation of a negative index of refraction," Science, Vol. 292, No. 5514, 77-79, Apr. 6, 2001.

8. Vrba, D. and M. Polivka, "Radiation efficiency improvement of zeroth-order resonator antenna," Radioengineering, Vol. 18, No. 1, 1-8, Apr. 2009.

9. Polivka, M. and D. Vrba, "Shielded micro-coplanar CRLH TL zeroth-order resonator antenna: Critical performance evaluation," Radioengineering, Vol. 18, No. 4, 368-372, Dec. 2009.

10. Wang, G. and Y. Gong, "Metamaterial lens applicator for microwave hyperthermia of breast cancer," International Journal of Hyperthermia, Vol. 25, No. 6, 434-445, 2009.

11. Leggio, L., O. de Varona, and E. Dadrasnia, "Comparison between different schemes of microwave cancer hyperthermia treatment by means of left-handed metamaterial lenses," Progress In Electromagnetics Research, Vol. 150, 73-87, 2015.

12. Vrba, D. and J. Vrba, "Novel applicators for local microwave hyperthermia based on zeroth-order mode resonator metamaterial," International Journal of Antennas and Propagation, Vol. 2014, 1-7, 2014.

13. Lee, E. R., T. R. Wilsey, P. Tarczyhornoch, D. S. Kapp, P. Fessenden, A. Lohrbach, and S. D. Prionas, "Body conformable 915MHz microstrip array applicators for large surface-area hyperthermia," IEEE Transactions on Biomedical Engineering, Vol. 39, No. 5, 470-483, May 1992.

14. Johnson, J. E., D. G. Neuman, P. F. Maccarini, T. Juang, P. R. Stauffer, and P. Turner, "Evaluation of a dual-arm Archimedean spiral array for microwave hyperthermia," International Journal of Hyperthermia, Vol. 22, No. 6, 475-490, Sep. 2006.

15. Rieke, V. and K. B. Pauly, "MR thermometry," Journal of Magnetic Resonance Imaging, Vol. 27, No. 2, 376-390, Feb. 2008.

16. Vrba, D., J. Vrba, and P. Stauffer, "Novel microwave applicators based on zero-order mode resonance for hyperthermia treatment of cancer," Proceedings of the IEEE BenMAS 2014, 107-109, Sep. 2014.

17. Ellison, W. J., "Permittivity of pure water, at standard atmospheric pressure, over the frequency range 0-25 THz and the temperature range 0-100 degrees C," Journal of Physical and Chemical Reference Data, Vol. 36, No. 1, 1-18, Mar. 2007.

18. Pennes, H. H., "Analysis of tissue and arterial blood temperatures in the resting human forearm," Journal of Applied Physiology, Vol. 1, 93-122, 1948.

19. Hasgall, P. A., F. Di Gennaro, E. Neufeld, M. C. Gosselin, D. Payne, A. Klingenbock, and N. Kuster, IT'IS Database for thermal and electromagnetic parameters of biological tissues, Version 2.6, Jan. 13, 2015.

20. Van der Gaag, M. L., M. de Bruijne, T. Samaras, J. van der Zee, and G. C. van Rhoon, "Development of a guideline for the water bolus temperature in super cial hyperthermia," International Journal of Hyperthermia, Vol. 22, No. 8, 637-656, Dec. 2006.

21. Stauffer, P. R., P. Maccarini, K. Arunachalam, O. Craciunescu, C. Diederich, T. Juang, F. Rossetto, J. Schlorff, A. Milligan, J.Hsu, P. Sneed, and Z. Vujaskovic, "Conformal microwave array (CMA) applicators for hyperthermia of diffuse chest wall recurrence," International Journal of Hyperthermia, Vol. 26, No. 7, 686-986, Oct. 2010.

22. Sekins, K. M., J. F. Lehmann, P. Esselman, D. Dundore, A. F. Emery, B. J. Delateur, and W. B. Nelp, "Local muscle blood- ow and temperature responses to 915MHz diathermy as simultaneously measured and numerically predicted," Archives of Physical Medicine and Rehabilitation, Vol. 65, No. 1, 1-7, Jan. 1984.

23. Waterman, F. M., R. E. Nerlinger, D. J. Moylan, and D. B. Leeper, "Response of human tumor blood ow to local hyperthermia," International Journal of Radiation Oncology Biology Physics, Vol. 13, No. 1, 75-82, Jan. 1987.

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