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APPLICATION OF PULSED MAGNETIC PONDEROMOTIVE FORCE FOR INTRA-CELLULAR GENE DELIVERY

By P. Babinec, A. Krafcik, M. Babincova, J. Rosenecker, and I. Frollo

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Abstract:
A novel method of the aerosolized gene delivery is proposed, and its feasibility is computationally analyzed. Aerosolized DNA or siRNA attached to magnetic particles can be accelerated using ponderomotive force to high velocities in a pulsed magnetic field of a solenoid and efficiently delivered to cell culture or to the lung epithelium. The proposed noninvasive method of intra-cellular gene delivery can be considered as a combination of principles of classical high-pressure air jet gene delivery with magnetophoresis.

Citation:
P. Babinec, A. Krafcik, M. Babincova, J. Rosenecker, and I. Frollo, "Application of Pulsed Magnetic Ponderomotive Force for Intra-Cellular Gene Delivery," Progress In Electromagnetics Research M, Vol. 37, 139-147, 2014.
doi:10.2528/PIERM14042907

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