volume | PIER Journals

Abstract

The design criteria of integrated optical biosensors based on the Mach-Zehnder Interferometer and on the Michelson Interferometer are proposed. Sensitive performance has been evaluated for different optical polymeric waveguiding structures such as channel, inverted-rib and strip waveguides. For all the configurations of the examined optical waveguiding interferometric biosensors maximum linearity and sensitivity have been obtained. In particular, the achieved sensitivity, expressed as the ratio between the normalized output power and the protein concentration, is about equal to 1.6 (g/ml)^-1 which, for a maximum variation of the output power equal to 100 mW, leads to a non-normalized sensitivity equal to 160 mW/(g/ml).

1. Banerjee, A., "Enhanced refractometric optical sensing by using one-dimensional ternary photonic crystals," Progress In Electromagnetics Research, Vol. 89, 11-22, 2009.
doi:10.2528/PIER08112105 Google Scholar

2. Massaro, A., F. Spano, P. Cazzato, R. Cingolani, and A. Athanassiou, "Innovative optical tactile sensor for robotic system by gold nanocomposite material," Progress In Electromagnetics Research M, Vol. 16, 145-158, 2011. Google Scholar

3. Mescia, L., F. Prudenzano, L. Allegretti, G. Calò, M. De Sario, A. D'Orazio, L. Maiorano, T. Palmisano, and V. Petruzzelli, "Design of silica-based photonic crystal fiber for biosensing applications," Journal of Non-Crystalline Solids, Vol. 355, 1163-1166, 2009.
doi:10.1016/j.jnoncrysol.2009.01.047 Google Scholar

4. D'Orazio, A., M. De Sario, C. Giasi, L. Mescia, V. Petruzzelli, and F. Prudenzano, "Design of planar optic sensors for hydrocarbon detection," Optical and Quantum Electronics, Vol. 36, No. 6, 507-526, 2004.
doi:10.1023/B:OQEL.0000025786.11522.a4 Google Scholar

5. Prudenzano, F., L. Mescia, L. A. Allegretti, G. Calò, A. D'Orazio, M. De Sario, T. Palmisano, and V. Petruzzelli, "Design of an optical sensor array for hydrocarbon monitoring," Optical and Quantum Electronics, 2009, DOI 10.1007/s11082-009-9322-1. Google Scholar

6. Vincenti, M. A., M. De Sario, V. Petruzzelli, A. D'Orazio, F. Prudenzano, D. De Ceglia, and M. Scalora, "Fabry-Perot microcavity sensor for H2-breath-test analysis," J. Applied Physics, Vol. 102, No. 7, 074501, 2007.
doi:10.1063/1.2785023 Google Scholar

7. Stomeo, T., V. Marrocco, V. Petruzzelli, F. Prudenzano, M. Grande, A. Qualtieri, A. Passaseo, and M. De Sario, "Fabrication of force sensors based on two-dimensional photonic crystal technology," Microelectronic Engineering, Vol. 84, No. 5--8, 1450-1453, 2007.
doi:10.1016/j.mee.2007.01.227 Google Scholar

8. Dostalek, J., J. Ctyroky, J. Homola, E. Brynda, M. Skalsky, P. Nekvindova, J. Spirkova, J. Skvor, and J. Schrofel, "Surface plasmon resonance biosensor based on integrated optical waveguide," Sens. Actuators B, Vol. 76, 8-12, 2001.
doi:10.1016/S0925-4005(01)00559-7 Google Scholar

9. Hopman, W. C. L., P. Pottier, D. Yudistira, J. van Lith, P. V. Lambeck, R. M. De La Rue, A. Driessen, H. J. W. M. Hoekstra, and R. M. de Ridder, "Quasi one-dimensional photonic crystal as a compact building-block for refractometric optical sensors," IEEE J. Sel. Top. in Quantum Electron., Vol. 11, 11-16, 2005.
doi:10.1109/JSTQE.2004.841693 Google Scholar

10. Luo, Z., T. Suyama, X. Xu, and Y. Okuno, "A grating-based plasmon biosensor with high resolution," Progress In Electromagnetics Research, Vol. 118, 527-539, 2011.
doi:10.2528/PIER11060103 Google Scholar

11. Singh, V. and D. Kumar, "Theoretical modeling of a metal-clad planar waveguide based biosensors for the detection of pseudomonas-like bacteria," Progress In Electromagnetics Research M, Vol. 6, 167-184, 2009.
doi:10.2528/PIERM09021701 Google Scholar

12. Prieto, F., B. Sepulveda, A. Calle, A. Llobera, C. Dominguez, and L. M. Lechug, "Integrated Mach-Zehnder interferometer based on ARROW structures for biosensor applications," Sens. Actuators B, Vol. 92, 151-158, 2003.
doi:10.1016/S0925-4005(03)00257-0 Google Scholar

13. Koerdt, M. and F. Vollertsen, "Fabrication of an integrated optical Mach{Zehnder interferometer based on refractive index modification of polymethylmethacrylate by krypton fluoride excimer laser radiation," Applied Surface Science, Vol. 257, 5237-5240, 2011.
doi:10.1016/j.apsusc.2010.11.039 Google Scholar

14. Lillie, J. J., M. A. Thomas, N.-M. Jokerst, S. E. Ralph, K. A. Dennis, and C. L. Henderson, "Multimode interferometric sensors on silicon optimized for fully integrated complementary metal-oxide-semiconductor chemical-biological sensor systems," J. Opt. Soc. Am. B, Vol. 23, 642-651, 2006.
doi:10.1364/JOSAB.23.000642 Google Scholar

15. Bruck, R., E. Melnik, P. Muellner, R. Hainberger, and M. Lammerhofer, "Integrated polymer-based Mach-Zehnder interferometer label-free streptavidin biosensor compatible with injection molding," Biosensors and Bioelectronics, Vol. 26, 3832-3837, 2011.
doi:10.1016/j.bios.2011.02.042 Google Scholar

16. Xu, Y., Y. Q. Li, Y. Jiang, and C. K. Y. Leung, "Application of 3×3 coupler based Mach-Zehnder interferometer in delamination patch detection in composite," NDT&E International, Vol. 44, 469-476, 2011.
doi:10.1016/j.ndteint.2011.04.009 Google Scholar

17. Melnik, E., R. Bruck, R. Hainberger, and M. Lämmerhofer, "Multi-step surface functionalization of polyimide based evanescent wave photonic biosensors and application for DNA hybridization by Mach-Zehnder interferometer," Analytica Chimica Acta, Vol. 699, 206-215, 2011.
doi:10.1016/j.aca.2011.05.017 Google Scholar

18. Duan, D.-W., Y.-J. Rao, L.-C. Xu, T. Zhu, D. Wu, and J. Yao, "In-fiber Mach-Zehnder interferometer formed by large lateral offset fusion splicing for gases refractive index measurement with high sensitivity," Sens. and Actuators B, Vol. 160, 1198-1202, 2011.
doi:10.1016/j.snb.2011.09.048 Google Scholar

19. Hong, J., J. S. Choi, G. Han, J. K. Kang, C.-M. Kim, T. S. Kim, and D. S. Yoon, "A Mach-Zehnder interferometer based on silicon oxides for biosensor applications," Analytica Chimica Acta, Vol. 573--574, 97-103, 2006.
doi:10.1016/j.aca.2006.04.045 Google Scholar

20. Qi, Z.-M., N. Matsuda, K. Itoh, M. Murabayashi, and C. R. Lavers, "A design for improving the sensitivity of a Mach-Zehnder interferometer to chemical and biological measurands," Sens. and Actuators B, Vol. 8, 254-258, 2002.
doi:10.1016/S0925-4005(01)00960-1 Google Scholar

21. Mosquera, L., J. H. Osório, J. G. Hayashi, and C. M. B. Cordeiro, "Refractometric sensor based on all-fiber coaxial Michelson and Mach-Zehnder interferometers for ethanol detection in fuel," Journal of Physics: Conference Series, Vol. 274, 012020, 2011.
doi:10.1088/1742-6596/274/1/012020 Google Scholar

22. Meng, H. Y., W. Shen, G. B. Zhang, X. W. Wu, W. Wang, C. Tan, and X. G. Huang, "Michelson interferometer-based fiber-optic sensing of liquid refractive index," Sens. and Actuators B, Vol. 160, 720-723, 2011.
doi:10.1016/j.snb.2011.08.054 Google Scholar

23. Llobera, A., V. J. Cadarso, M. Darder, C. Domìnguez, and C. Fernàndez-Sànchez, "Full-field photonic biosensors based on tunable bio-doped sol-gel glasses," Lab Chip, Vol. 8, 1185-1190, 2008.
doi:10.1039/b801152d Google Scholar

24. Stangegaard, M., Z. Wang, J. P. Kutter, M. Dufva, A. Wolff, and , "Whole genome expression profiling using DNA microarray for determining biocompatibility of polymeric surfaces," Mol. BioSyst, Vol. 2, 421-428, 2006.
doi:10.1039/b608239d Google Scholar

25. Koerdt, M. and F. Vollertsen, "Fabrication of an integrated optical Mach{Zehnder interferometer based on refractive index modification of polymethylmethacrylate by krypton fluoride excimer laser radiation," Applied Surface Science, Vol. 257, 5237-5240, 2011.
doi:10.1016/j.apsusc.2010.11.039 Google Scholar

26. Esinenco, D., S. D. Psoma, M. Kusko, A. Schneider, and R. Muller, "SU-8 Micro-Biosensor based on Mach-Zehnder Interferometer," Rev. Adv. Mater. Sci, Vol. 10, 295-299, 2005. Google Scholar

27. Lu, B. J., et al. "Integrated optical Mach-Zehnder biosensor," J. Light. Tech., Vol. 16, No. 4, 583-592, 1998.
doi:10.1109/50.664067 Google Scholar

28. De Sario, M., A. D'Orazio, and V. Lanave, "Realistic design of a WDM duplexer made from LiNbO3 optical filters," J. Phys. D, Vol. 21, s147-s149, 1988.
doi:10.1088/0022-3727/21/10S/042 Google Scholar

29. Buus, J., "The effective index method and its application to semiconductor laser," IEEE J. Quant. Elect., Vol. 18, 1083-1089, 1982.
doi:10.1109/JQE.1982.1071659 Google Scholar

30. Liu, J.-M., Photonic Devices, Cambridge University Press, 2005.
doi:10.1017/CBO9780511614255

31. D'Alessandro, A., F. Campoli, P. Maltese, G. Chessa, A. D'Orazio, and V. Petruzzelli, "Design of an ultrashort directional coupler with an SSFLC coupling layer," Molecular Crystals and Liquid Crystals, Vol. 320, 355-364, 1998. Google Scholar

32. DeFeijter, J. A., J. Benjamins, and F. A. Veer, "Ellipsometry as a tool to study the adsorption behavior of synthetic and biopolymers at the air-water interface," Biopolymers, Vol. 17, 1759-1772, 1978.
doi:10.1002/bip.1978.360170711 Google Scholar

Dr. Giovanna Calo

Dr. Antonio Farinola

Professor Vincenzo Petruzzelli