volume | PIER Journals

Abstract

Microwave induced thermo-acoustic tomography (MITAT) is a developing technique for biomedical applications, especially for early breast cancer detection. In this paper, impacts of short microwave pulse on thermo-acoustic (TA) signals are analyzed and verified through some experimental comparisons. In these experiments, short microwave pulses with widths of 10 ns and 500 ns are employed as radiation resources. TA signals generated from a cubic sample are analyzed in both time- and frequency-domain. A trapezoid sample is also performed for experimental comparing. Different from previous literature, the effects of rising edge of radiation microwave pulse have been intensively studied. Experimental results demonstrate that shorter rising edge duration conducts broader bandwidth of TA signal, which give rise to better spatial resolution for tomography imaging.

1. Lin, J. C., "On microwave-induced hearing sensation," IEEE Trans. Microw. Theory Techn., Vol. 25, 605-613, 1977.
doi:10.1109/TMTT.1977.1129167 Google Scholar

2. Lazebnik, M., D. Popovic, L. McCartney, C. B. Watkins, M. J. Lindstrom, J. Harter, S. Sewall, T. Ogilvie, A. Magliocco, and T. M. Breslin, "A large-scale study of the ultrawideband microwave dielectric properties of normal, benign and malignant breast tissues obtained from cancer surgeries," Phys. Med. Biol., Vol. 52, No. 20, 6093, 2007.
doi:10.1088/0031-9155/52/20/002 Google Scholar

3. Catapano, I., L. Di Donato, L. Crocco, O. M. Bucci, A. F. Morabito, T. Isernia, and R. Massa, "On quantitative microwave tomography of female breast," Progress In Electromagnetics Research, Vol. 97, 75-93, 2009.
doi:10.2528/PIER09080604 Google Scholar

4. Zastrow, E., S. K. Davis, M. Lazebnik, F. Kelcz, B. D. van Veen, and S. C. Hagness, "Development of anatomically realistic numerical breast phantoms with accurate dielectric properties for modeling microwave interactions with the human breast," IEEE Trans. Med. Imag., Vol. 55, No. 12, 2792-2800, 2008. Google Scholar

5. Wang, L. V., X. Zhao, H. Sun, and G. Ku, "Microwave-induced acoustic imaging of biological tissues," Rev. Sci. Instrum., Vol. 70, No. 9, 3744-3748, 1999.
doi:10.1063/1.1149986 Google Scholar

6. Gao, F., Y. Zheng, X. Feng, and C. D. Ohl, "Thermoacoustic resonance effect and circuit modelling of biological tissue," Appl. Phys. Lett., Vol. 102, No. 6, 063702, 2013.
doi:10.1063/1.4791791 Google Scholar

7. Qin, T., X.Wang, Y. Qin, P. Ingram, G.-B.Wan, R. S. Witte, and H. Xin, "Experimental validation of a numerical model for thermoacoustic imaging applications," IEEE Antennas Wireless Propag. Lett., Vol. 14, 1235-1238, 2015.
doi:10.1109/LAWP.2014.2384022 Google Scholar

8. Ku, G. and L. V. Wang, "Scanning thermoacoustic tomography in biological tissue," Med. Phys., Vol. 27, 1195-1202, 2000.
doi:10.1118/1.598984 Google Scholar

9. Ku, G. and L. V. Wang, "Scanning microwave-induced thermoacoustic tomography: Signal, resolution, and contrast," Med. Phys., Vol. 28, 4-10, 2001.
doi:10.1118/1.1333409 Google Scholar

10. Wang, X., D. R. Bauer, J. L. Vollin, D. G. Manzi, R. S. Witte, and H. Xin, "Impact of microwave pulses on thermoacoustic imaging applications," IEEE Antennas Wireless Propag. Lett., Vol. 11, 1634-1637, 2012.
doi:10.1109/LAWP.2013.2237743 Google Scholar

11. Lou, C., L. Nie, and D. Xu, "Effect of excitation pulse width on thermoacoustic signal characteristics and the corresponding algorithm for optimization of imaging resolution," J. Appl. Phys., Vol. 110, 083101, 2011.
doi:10.1063/1.3651636 Google Scholar

12. Lou, C., S. Yang, Z. Ji, Q. Chen, and D. Xing, "Ultrashort microwave-induced thermoacoustic imaging: A breakthrough in excitation efficiency and spatial resolution," Phys. Rev. Lett., Vol. 109, 218101, 2012.
doi:10.1103/PhysRevLett.109.218101 Google Scholar

13. Diebold, G., T. Sun, and M. Khan, "Photoacoustic monopole radiation in one, two, and three dimensions," Phys. Rev. Lett., Vol. 67, No. 24, 3384, 1991.
doi:10.1103/PhysRevLett.67.3384 Google Scholar

14. Omar, M., J. Gateau, and V. Ntziachristos, "Raster-scan optoacoustic mesoscopy in the 25-125 MHz range," Opt. Lett., Vol. 38, No. 14, 2472-2474, 2013.
doi:10.1364/OL.38.002472 Google Scholar

15. Razansky, D., S. Kellnberger, and V. Ntziachristos, "Near-field radiofrequency thermoacoustic tomography with impulse excitation," Med. Phys., Vol. 37, 4602-4607, 2010.
doi:10.1118/1.3467756 Google Scholar

16. Rosenthal, A., D. Razansky, and V. Ntziachristos, "Fast semi-analytical model-based acoustic inversion for quantitative optoacoustic tomography," IEEE Trans. Med. Imag., Vol. 29, 1275-1285, 2010.
doi:10.1109/TMI.2010.2044584 Google Scholar

17. Xu, M. and L. V. Wang, "Time-domain reconstruction for thermoacoustic tomography in a spherical geometry," IEEE Trans. Med. Imag., Vol. 21, 814-822, 2002. Google Scholar

18. Guy, A. W., "Analyses of electromagnetic fields induced in biological tissues by thermographic studies on equivalent phantom models," IEEE Trans. Microw. Theory Techn., Vol. 16, No. 2, 205-214, 1971.
doi:10.1109/TMTT.1968.1127484 Google Scholar

19. Song, J., Z. Zhao, J. Wang, X. Zhu, J. Wu, Z. Nie, et al. "Evaluation of contrast enhancement by Carbon Nanotubes for microwave induced thermo-acoustic tomography," IEEE Trans. Biomed. Eng., Vol. 62, 939-938, 2014. Google Scholar

20. Zhao, Z., J. Song, X. Zhu, J. Wang, J. Wu, Y. Liu, Z.-P. Nie, and Q. H. Liu, "System development of microwave induced thermo-acoustic tomography and experiments on breast tumor," Progress In Electromagnetics Research, Vol. 134, 323-336, 2013.
doi:10.2528/PIER12101604 Google Scholar

21. Song, J., Z. Zhao, J. Wang, X. Zhu, J. Wu, Z.-P. Nie, and Q. H. Liu, "An integrated simulation approach and experimental research on microwave induced thermo-acoustic tomography system," Progress In Electromagnetics Research, Vol. 140, 385-400, 2013.
doi:10.2528/PIER13041704 Google Scholar

22. Hristova, Y., P. Kuchment, and L. Nguyen, "Reconstruction and time reversal in thermoacoustic tomography in acoustically homogeneous and inhomogeneous media," Inverse Problems, Vol. 24, 055006, 2008.
doi:10.1088/0266-5611/24/5/055006 Google Scholar

23. Zheng, W., Z. Zhao, Z.-P. Nie, and Q. H. Liu, "Evaluation of TRM in the complex through wall environment," Progress In Electromagnetics Research, Vol. 90, 235-254, 2009.
doi:10.2528/PIER09011003 Google Scholar

24. Deán-Ben, X. L., D. Razansky, and V. Ntziachristos, "The effects of acoustic attenuation in optoacoustic signals," Phys. Med. Biol., Vol. 56, No. 18, 6129, 2011.
doi:10.1088/0031-9155/56/18/021 Google Scholar

25. Xu, Y. and L. V. Wang, "Effects of acoustic heterogeneity in breast thermoacoustic tomography," IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, Vol. 50, No. 9, 1134-1146, 2003.
doi:10.1109/TUFFC.2003.1235325 Google Scholar

Ms. Shuangli Liu

Professor Zhiqin Zhao

Dr. Xiaozhang Zhu

Dr. Zhan-Liang Wang

Dr. Jian Song

Dr. Bingwen Wang

Dr. Yu-Bin Gong

Professor Zai-Ping Nie

Prof. Qing Huo Liu