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2014-07-16
Application of Pulsed Magnetic Ponderomotive Force for Intra-Cellular Gene Delivery
By
Progress In Electromagnetics Research M, Vol. 37, 139-147, 2014
Abstract
A novel method of the aerosolized gene delivery is proposed, and its feasibility is computationally analyzed. Aerosolized DNA or siRNA attached to magnetic particles can be accelerated using ponderomotive force to high velocities in a pulsed magnetic field of a solenoid and efficiently delivered to cell culture or to the lung epithelium. The proposed noninvasive method of intra-cellular gene delivery can be considered as a combination of principles of classical high-pressure air jet gene delivery with magnetophoresis.
Citation
Peter Babinec Andrej Krafcik Melania Babincova Joseph Rosenecker Ivan Frollo , "Application of Pulsed Magnetic Ponderomotive Force for Intra-Cellular Gene Delivery," Progress In Electromagnetics Research M, Vol. 37, 139-147, 2014.
doi:10.2528/PIERM14042907
http://www.jpier.org/PIERM/pier.php?paper=14042907
References

1. Babincova, M., K. Kontrisova, S. Durdik, C. Bergemann, and P. Sourivong, "Radiation enhanced efficiency of combined electromagnetic hyperthermia and chemotherapy of lung carcinoma using cisplatin functionalized magnetic nanoparticles," Pharmazie, Vol. 69, No. 2, 128-131, 2014.

2. Durdik, S., A. Krafcik, M. Babincova, and P. Babinec, "Conceptual design of integrated microfluidic system for magnetic cell separation, electroporation, and transfection," Phys. Med., Vol. 29, No. 5, 562-567, 2013.
doi:10.1016/j.ejmp.2012.11.003

3. Durdik, S., H. Vrbovska, A. Olas, and M. Babincova, "Influence of naturally occurring antioxidants on magnetic nanoparticles: Risks, benefis, and possible therapeutic applications," Gen. Physiol. Biophys., Vol. 32, No. 2, 173-177, 2013.
doi:10.4149/gpb_2013039

4. Durdik, S., M. Babincova, C. Bergemann, and P. Babinec, "Nanosecond laser pulse induced stress waves enhanced: Magnetofection of human carcinoma cells in vitro," Laser Phys. Lett., Vol. 9, No. 9, 678-681, 2012.
doi:10.7452/lapl.201210064

5. Krafcik, A., P. Babinec, and M. Babincova, "Feasibility of subcutaneously implanted magnetic microarrays for site specific drug and gene targeting," J. Eng. Sci. Technol. Rev., Vol. 3, No. 1, 53-57, 2010.

6. Babinec, P., A. Krafcik, M. Babincova, and J. Rosenecker, "Dynamics of magnetic particles in cylindrical Halbach array: Implications for magnetic cell separation and drug targeting," Med. Biol. Eng. Comput., Vol. 48, No. 8, 745-753, 2010.
doi:10.1007/s11517-010-0636-8

7. Babincova, M. and P. Babinec, "Magnetic drug delivery and targeting: Principles and applications," Biomed. Pap., Vol. 153, No. 4, 243-250, 2009.
doi:10.5507/bp.2009.042

8. Krafcik, A., M. Babincova, and P. Babinec, "Theoretical analysis of magnetic particle trajectory in high-current pulsed quadrupole: Implications for magnetic cell separation, drug targeting, and gene therapy," Opto. Adv. Mat. Rap. Comm., Vol. 3, No. 3, 226-230, 2009.

9. Babincova, M., V. Altanerova, C. Altaner, C. Bergemann, and P. Babinec, "In vitro analysis of cisplatin functionalized magnetic nanoparticles in combined cancer chemotherapy and electromagnetic hyperthermia," IEEE Trans. Nanobiosci., Vol. 7, No. 1, 15-19, 2008.
doi:10.1109/TNB.2008.2000145

10. Babincova, M. and P. Babinec, "Aerosolized VEGF in combination with intravenous magnetically targeted delivery of DNA-nanoparticle complex may increase efficiency of cystic fibrosis gene therapy," Med. Hypotheses, Vol. 67, No. 4, 1002, 2006.
doi:10.1016/j.mehy.2006.05.001

11. Babinec, P. and M. Babincova, "Genetically engineered bacteria may be useful for delivery of mucolytics into cystic fibrosis lungs," Med. Hypotheses, Vol. 67, No. 2, 426-427, 2006.
doi:10.1016/j.mehy.2006.03.013

12. Babincova, M., V. Altanerova, C. Altaner, P. Cicmanec, and P. Babinec, "In vivo heating of magnetic nanoparticles in alternating magnetic field," Med. Phys., Vol. 31, No. 8, 2219-2221, 2004.
doi:10.1118/1.1767101

13. Babincova, M., P. Babinec, and C. Bergemann, "High-gradient magnetic capture of ferrofiuids: Implications for drug targeting and tumor embolization," Zeitschrift fur Naturforschung --- Section C Journal of Z. Naturforsch. Sect. C J. Biosci., Vol. 56, No. 9-10, 909-911, 2001.

14. Yanai, A., U. O. Hafeli, A. L. Metcalfe, P. Soema, L. Addo, C. Y. Gregory-Evans, K. Po, X. Shan, O. L. Moritz, and K. Gregory-Evans, "Focused magnetic stem cell targeting to the retina using superparamagnetic iron oxide nanoparticle," Cell Transplant., Vol. 21, No. 6, 1137-1148, 2012.
doi:10.3727/096368911X627435

15. Hafeli, U. O., K. Saatchi, P. Elischer, R. Misri, M. Bokharaei, N. Renee Labiris, and B. Stoeber, "Lung perfusion imaging with monosized biodegradable microspheres," Biomacromolecules, Vol. 11, No. 3, 561-567, 2010.
doi:10.1021/bm9010722

16. Hayden, M. E. and U. O. Hafeli, "Magnetic bandages' for targeted delivery of therapeutic agents," J. Phys. Condens. Matter, Vol. 18, No. 38, S2877-S2891, 2006.
doi:10.1088/0953-8984/18/38/S23

17. Conese, M., F. Ascenzioni, A. C. Boyd, C. Coutelle, I. De Fino, S. De Smedt, J. Rejman, J. Rosenecker, D. Schindelhauer, B. J. Scholte, and , "Gene and cell therapy for cystic fibrosis: From bench to bedside," J. Cyst. Fibrosis, Vol. 10, No. 2, S114-S128, 2011.
doi:10.1016/S1569-1993(11)60017-9

18. Rosenecker, J., "The long and winding road to clinical success in gene therapy," Curr. Opin. Mol. Ther., Vol. 12, No. 5, 507-508, 2010.

19. Griesenbach, U. and E. W. F. W. Alton, "Moving forward: Cystic fibrosis gene therapy," Hum. Mol. Genet., Vol. 22, No. R1, R52-R58, 2013.
doi:10.1093/hmg/ddt372

20. Griesenbach, U. and E. W. F. W. Alton, "Progress in gene and cell therapy for cystic fibrosis lung disease," Curr. Pharm. Des., Vol. 18, No. 5, 642-662, 2012.
doi:10.2174/138161212799315993

21. Bangel-Ruland, N., K. Tomczak, E. Fernandez Fernandez, G. Leier, B. Leciejewski, C. Rudolph, J. Rosenecker, and W.-M. Weber, "Cystic fibrosis transmembrane conductance regulator-mRNA delivery: A novel alternative for cystic fibrosis gene therapy," J. Gene Med., Vol. 15, No. 11-12, 414-426, 2013.
doi:10.1002/jgm.2748

22. Sanders, N., C. Rudolph, K. Braeckmans, S. C. De Smedt, and J. Demeester, "Extracellular barriers in respiratory gene therapy," Adv. Drug Deliv. Rev., Vol. 61, No. 2, 115-127, 2009.
doi:10.1016/j.addr.2008.09.011

23. Chandolu, V. and C. R. Dass, "Treatment of lung cancer using nanoparticle drug delivery systems," Curr. Drug Discov. Technol., Vol. 10, No. 2, 170-176, 2013.
doi:10.2174/1570163811310020010

24. Baumann, R., G. Glockl, S. Nagel, and W. Weitschies, "Preparation and characterization of magnetizable aerosols," Eur. J. Pharm. Sci., Vol. 45, No. 5, 693-697, 2012.
doi:10.1016/j.ejps.2012.01.009

25. Xie, Y., P. W. Longest, Y. H. Xu, J. P. Wang, and T. S. Wiedmann, "In vitro and in vivo lung deposition of coated magnetic aerosol particles," J. Pharm. Sci., Vol. 99, No. 11, 4658-4668, 2010.
doi:10.1002/jps.22168

26. Dahmani, C., S. Gotz, T.Weyh, R. Renner, M. Rosenecker, and C. Rudolph, "Respiration triggered magnetic drug targeting in the lungs," Conf. Proc. IEEE Eng. Med. Biol. Soc., Vol. 2009, 5440-5443, 2009.

27. Plank, C., "Nanomagnetosols: magnetism opens up new perspectives for targeted aerosol delivery to the lung," Trends Biotechnol., Vol. 26, No. 2, 59-63, 2008.
doi:10.1016/j.tibtech.2007.11.001

28. Coates, A. L., "Guiding aerosol deposition in the lung," New Engl. J. Med., Vol. 358, No. 3, 304-305, 2008.
doi:10.1056/NEJMcibr0707489

29. Dames, P., B. Gleich, A. Flemmer, K. Hajek, N. Seidl, F. Wiekhorst, D. Eberbeck, I. Bittmann, C. Bergemann, T.Weyh, L. Trahms, J. Rosenecker, and C. Rudolph, "Targeted delivery of magnetic aerosol droplets to the lung," Nat. Nanotechnol., Vol. 2, No. 8, 495-499, 2007.
doi:10.1038/nnano.2007.217

30. Hasenpusch, G., J. Geiger, K. Wagner, O. Mykhaylyk, F. Wiekhorst, L. Trahms, A. Heidsieck, B. Gleich, C. Bergemann, M. K. Aneja, and C. Rudolph, "Magnetized aerosols comprising superparamagnetic iron oxide nanoparticles improve targeted drug and gene delivery to the lung," Pharm. Res., Vol. 29, No. 5, 1308-1318, 2012.
doi:10.1007/s11095-012-0682-z

31. Goetz, S. M., C. Dahmani, C. Rudolph, and T. Weyh, "First theoretic analysis of magnetic drug targeting in the lung," IEEE Trans. Biomed. Eng., Vol. 57, No. 9, 2115-2121, 2010.
doi:10.1109/TBME.2010.2051032

32. Pfeifer, C., A. Himmel, J.-P. Geiger, M. K. Aneja, and C. Rudolph, "Efficient, specific and targeted delivery of genes to the lung," Ther. Deliv., Vol. 1, No. 1, 133-148, 2010.
doi:10.4155/tde.10.11

33. Sanford, J. C., "Turning point article: The development of the biolistic process," In Vitro Cell. Dev. Biol. Plant, Vol. 36, No. 5, 303-308, 2000.
doi:10.1007/s11627-000-0056-9

34. Ye, X., S. K. Brown, R. Scorza, J. Cordts, and J. C. Sanford, "Genetic transformation of peach tissues by particle bombardment," J. Am. Soc. Hortic. Sci., Vol. 119, No. 2, 367-373, 1994.

35. Sanford, J. C., F. D. Smith, and J. A. Russell, "Optimizing the biolistic process for different biological applications," Methods Enzymol., Vol. 217, 483-509, 1993.
doi:10.1016/0076-6879(93)17086-K

36. Sanford, J. C., T. M. Klein, E. D. Wolf, and N. Allen, "Delivery of substances into cells and tissues using a particle bombardment process," Particulate Sci. Technol., Vol. 5, 27-37, 1987.
doi:10.1080/02726358708904533

37. Lee, S.-J., J.-H. Kim, B. S. Song, and J. H. Kim, "Coil gun electromagnetic launcher (EML) system with multi-stage electromagnetic coils," J. Magn., Vol. 18, No. 4, 481-486, 2013.
doi:10.4283/JMAG.2013.18.4.481

38. Roch, M., S. Hundertmark, M. Loffler, and P. Zacharias, "Augmented electromagnetic accelerators --- Technical solutions and new ideas," IEEE Trans. Plasma Sci., Vol. 41, No. 10, 2810-2814, 2013.
doi:10.1109/TPS.2013.2280762

39. Li, Z., S. Cheng, P. Zheng, M. Feng, and Y. Cao, "Finite-element analysis for the active electromagnetic armor projectile interceptor," IEEE Trans. Magn., Vol. 41, No. 1, 453-455, 2005.
doi:10.1109/TMAG.2004.838971

40. Furlani, E. P. and K. C. Ng, "Analytical model of magnetic nanoparticle transport and capture in the microvasculature," Phys. Rev. E Stat. Nonlinear Soft Matter Phys., Vol. 73, No. 6, 061919, 2006.
doi:10.1103/PhysRevE.73.061919

41. Shampine, L. F. and M. W. Reichelt, "The MATLAB ode suite," SIAM J. Sci. Comput., Vol. 18, No. 1, 1-22, 1997.
doi:10.1137/S1064827594276424

42. Heyder, J., J. Gebhart, and G. Scheuch, "Interaction of diffusional and gravitational particle transport in aerosols," Aerosol Sci. Technol., Vol. 4, No. 3, 315-326, 1985.
doi:10.1080/02786828508959058

43. Beatrice, C., O. Bottauscio, E. Ferrara, F. Fiorillo, and E. Patroi, "Characterization of permanent magnets with the pulsed field magnetizer," J. Optoelectron. Adv. Mat., Vol. 6, No. 3, 963-968, 2004.