volume | PIER Journals

Abstract

Magnetic nanoparticles (MNPs) have been widely investigated as effective drug carriers for targeted tumor therapy. However, the successful application of this technology in the human body requires reliable imaging support. Magnetoacoustic Concentration Tomography of Magnetic Nanoparticles with Magnetic Induction (MACT-MI) is an electromagnetic-ultrasonic coupling imaging technique that holds great promise in improving imaging resolution and providing unique advantages for tumor monitoring and treatment. To evaluate the imaging feasibility of MACT-MI technology for targeted therapy of breast tumors, this study establishes a realistic breast model and takes into account the distribution of magnetic particles within the actual breast tissue environment. A concentration gradient model is introduced, and the finite element method is employed to solve the electromagnetic and sound fields. In addressing the research objective, the forward problem is investigated by analyzing the magnetic force and sound pressure distribution for various tumor sizes and locations, different breast tissues, and both benign and malignant tumors. The results obtained indicate that the magnetoacoustic signal emitted by magnetic particles facilitates accurate mapping of the size and location information of magnetic particles enveloping breast tumors, as well as distinguishing between benign and malignant tumors.

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Dr. Xiaoheng Yan

Mr. Fangtian Liu

Dr. Waldemar Tomasz Smolik

Dr. Xinxian Dan

Dr. Xiaohan Hou