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PIER PIER B PIER C PIER M PIER Letters
2022-11-10
Noninvasive Raman Imaging for Monitoring Mitochondrial Redox State in Septic Rats
By
Changwei Jiao,

    Mr. Changwei Jiao

    Zhejiang University

    China

    Homepage

Zijian Lin,

    Mr. Zijian Lin

    College of Optical Science and Engineering

    Zhejiang University

    China

    Homepage

Yinghe Xu,

    Dr. Yinghe Xu

    Department of Intensive Care Unit

    Taizhou Hospital of Zhejiang Province

    China

    Homepage

Sailing He

    Prof. Sailing He

    Department of Electromagnetic Theory

    Royal Institute of Technology

    Sweden

    Homepage

Progress In Electromagnetics Research, Vol. 175, 149-157, 2022
doi:10.2528/PIER22101504
Abstract
Raman imaging for a sepsis study is reported here for the first time. We propose a confocal resonance Raman microscopic imager (CRRMI)to measure in vivo the redox state of mitochondria over a surface area of a septic rat. The CRRMI has excellent performance with spectral and spatial resolutions of 0.1 nm and 2 um, respectively. It is found for the first time that the Raman signal related to the mitochondrial dysfunction in sepsis is abnormally large only locally at many points with some random spatial distribution. Our CRRMI can detect the mitochondrial redox state through the skin of a naturally living rat even without the removal of hairs, and overcomes some issues that a pointwise measurement method of Raman signalsmay encounter when monitoring mitochondrial dysfunction of a sepsis rat, such as the fluorescence of hairs, hitting the points without mitochondrial redox metabolic disorder, etc.The present Raman imager can be used for giving an early warning for sepsis. It provides a new method for noninvasive monitoring of mitochondrial redox status in sepsis.
Citation
Changwei Jiao, Zijian Lin, Yinghe Xu, and Sailing He, "Noninvasive Raman Imaging for Monitoring Mitochondrial Redox State in Septic Rats," Progress In Electromagnetics Research, Vol. 175, 149-157, 2022.
doi:10.2528/PIER22101504
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