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PIER PIER B PIER C PIER M PIER Letters
2011-11-01
Using Nanoparticles for Enhancing the Focusing Heating Effect of an External Waveguide Applicator for Oncology Hyperthermia: Evaluation in Muscle and Tumor Phantoms
By
Citlalli Jessica Trujillo-Romero,

    Dr. Citlalli Jessica Trujillo-Romero

    Department of Electrical Engineering

    Cinvestav-IPN

    México

    Homepage

Sonia Garcia-Jimeno,

    Dr. Sonia Garcia-Jimeno

    Departament de Fisicoquímica

    Universitat de Barcelona

    Spain

    Homepage

Arturo Vera-Hernandez,

    Dr. Arturo Vera-Hernandez

    Department of Electrical Engineering

    Cinvestav-IPN

    México

    Homepage

Lorenzo Leija-Salas,

    Dr. Lorenzo Leija-Salas

    Department of Electrical Engineering

    Cinvestav-IPN

    México

    Homepage

Joan Estelrich

    Dr. Joan Estelrich

    Departament de Fisicoquímica

    Universitat de Barcelona

    Spain

    Homepage

Progress In Electromagnetics Research, Vol. 121, 343-363, 2011
doi:10.2528/PIER11092911
Abstract
A technical challenge in hyperthermia therapy is to locally heat the tumor region up to an appropriate temperature to destroy cancerous cells, without damaging the surrounding healthy tissue. Magnetic fluid hyperthermia (MFH) is a novel, minimally invasive therapy aiming at concentrating heat inside cancerous tissues. This therapy is based on the injection of different superparamagnetic nanoparticles inside the tumor. In our study, superparamagnetic nanoparticles, which we developed and characterized, consisted of iron oxide nanoparticles stabilized with polyethylene glycol. Moreover, a new technique for MFH using a specially designed external electromagnetic waveguide as applicator is presented. Three magnetite concentrations were used for making the tumor phantoms, which were embedded in muscle phantoms. The phantoms were radiated and located at three different distances from the applicator. Furthermore, two volumes of tumor (2.5 mL and 5.0 mL) were assayed. Heating curves, as a function of time, allowed the establishment of a more appropriate nanoparticle concentration for obtaining the temperature increase suitable for hyperthermia therapy. The results shown in this paper confirm the feasibility of using nanoparticles as agents to focus the energy over the tumor, without creating hot spots in healthy tissue. In addition, the experiments validated that by using this applicator in combination with nanoparticles, it is also possible to locally control the increments of temperature in tissues.
Citation
Citlalli Jessica Trujillo-Romero, Sonia Garcia-Jimeno, Arturo Vera-Hernandez, Lorenzo Leija-Salas, and Joan Estelrich, "Using Nanoparticles for Enhancing the Focusing Heating Effect of an External Waveguide Applicator for Oncology Hyperthermia: Evaluation in Muscle and Tumor Phantoms," Progress In Electromagnetics Research, Vol. 121, 343-363, 2011.
doi:10.2528/PIER11092911
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