In the hyperthermia therapy, multiple microwave sources can be arranged with appropriate spacing around the tissue containing tumor by using left-handed material (LHM) lenses. We employ some low loss LHM lenses schemes for an effective non-invasive microwave hyperthermia treatment of large tumors up to several centimeters of depth inside the biological tissues. Different configurations of LHM lenses are proposed and compared in order to assess the efficiency of hyperthermia treatment. High-resolution focusing of microwave radiation can be achieved by joint heating of several microwave antennas behind a conformal flat LHM lens. We show that a microwave radiation can be effectively focused in a 1.2 cm diameter tumor located within a lossy breast tissue. The results show that hyperthermia (temperature over 42°) is reached and then maintained for one hour without involving the surrounding healthy tissues. Lastly, the heating area is adjusted in both lateral and longitudinal directions changing the position of the microwave sources or selecting LHM lenses with different thickness. This approach confirms that the conformal four-lens system is more efficient to achieve microwave tumor hyperthermia than single- and double-lens schemes.
Omar de Varona,
"A Comparison Between Different Schemes of Microwave Cancer Hyperthermia Treatment by Means of Left-Handed Metamaterial Lenses," Progress In Electromagnetics Research,
Vol. 150, 73-87, 2015. doi:10.2528/PIER14101408
1. Nguyen, P. T., A. M. Abbosh, and S. Crozier, "Realistic simulation environment to test microwave hyperthermia treatment of breast cancer," IEEE International Symposium on Antennas and Propagation and USNC-URSI Radio Science Meeting, 1188-1189, 2014.
2. Trefna, H. D., J. Vrba, and M. Persson, "Time-reversal focusing in microwave hyperthermia for deep-seated tumors," Physics in Medicine and Biology, Vol. 55, No. 8, 2167-2185, 2010. doi:10.1088/0031-9155/55/8/004
3. Wang, G., Y. Gong, and H. J.Wang, "Schemes of microwave hyperthermia by using flat left-handed material lenses," Microwave and Optical Technology Letters, Vol. 51, No. 7, 1738-1743, 2009. doi:10.1002/mop.24449
4. Gong, Y. and G. Wang, "Superficial tumor hyperthermia with flat left-handed metamaterial lens," Progress In Electromagnetics Research, Vol. 98, 389-405, 2009. doi:10.2528/PIER09091401
5. Aydin, K., I. Bulu, and E. Ozbay, "Subwavelength resolution with a negative-index metamaterial superlens," Applied Physics Letters, Vol. 90, No. 25, 254102, 2007. doi:10.1063/1.2750393
7. Pendry, J. B. and S. A. Ramakrishna, "Refining the perfect lens," Physica B: Physics of Condensed Matter, Vol. 338, No. 1, 329-332, 2003. doi:10.1016/j.physb.2003.08.014
8. Garcia, N. and M. Nieto-Vesperinas, "Left-handed materials do not make a perfect lens," Physical Review Letter, Vol. 90, 229903, 2003. doi:10.1103/PhysRevLett.90.229903
9. Veselago, V. G., "The electrodynamics of substances with simultaneously negative values of ε and μ," Soviet Physics Uspekhi, Vol. 10, No. 4, 509-514, 1968. doi:10.1070/PU1968v010n04ABEH003699
10. Aydin, K. and E. Ozbay, "Left-handed metamaterial based superlens for subwavelength imaging of electromagnetic waves," Applied Physics A, Vol. 87, No. 2, 137-141, 2007. doi:10.1007/s00339-006-3817-4
11. Aydin, K., I. Bulu, and E. Ozbay, "Electromagnetic wave focusing from sources inside a two-dimensional left-handed material superlens," New Journal of Physics, Vol. 221, No. 8, 2006.
12. Pendry, J. B., A. J. Holden, D. J. Robbins, and W. J. Stewart, "Low frequency plasmons in thin-wire structures," Journal of Physics: Condensed Matter, Vol. 10, No. 22, 1998. doi:10.1088/0953-8984/10/22/007
13. Aydin, K., I. Bulu, K. Guven, M. Kafesaki, C. M. Soukoulis, and E. Ozbay, "Investigation of magnetic resonances for different split-ring resonator parameters and designs," New Journal of Physics, Vol. 7, No. 1, 168-1-168-15, 2005.
14. Smith, D. R., W. J. Padilla, D. C. Vier, S. C. Nemat-Nasser, and S. Schultz, "Composite medium with simultaneously negative permeability and permittivity," Physical Review Letters, Vol. 84, No. 18, 2000. doi:10.1103/PhysRevLett.84.4184
15. Fang, N. and X. Zhang, "Imaging properties of a metamaterial superlens," Applied Physics Letters, Vol. 82, No. 2, 161-163, 2003. doi:10.1063/1.1536712