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PIER PIER B PIER C PIER M PIER Letters PIER Photonics
2009-12-01
Chitosan Spheroids with Microwave Modulated Drug Release
By
Zakaria Zabliza,

    Dr. Zakaria Zabliza

    Universiti Teknologi MARA

    Malaysia

    Homepage

Tin Wui Wong

    Prof. Tin Wui Wong

    iPROMISE

    Universiti Teknologi MARA

    Malaysia

    Homepage

Progress In Electromagnetics Research, Vol. 99, 355-382, 2009
doi:10.2528/PIER09101001 | Google Scholar

Abstract
The interplay effects of matrix formulations with microwave on drug release were investigated using an agglomerate system. Chitosan spheroids were formulated with stearic acid and/or sodium chloride by extrusion-spheronization technique, and chlorpheniramine maleate as water-soluble model drug. The spheroids were treated by microwave at 80 W for 5 to 40 min. The profiles of drug dissolution, drug content, drug-polymer interaction, polymer-polymer interaction, sodium leaching, matrix morphology and integrity were determined. Unlike chitosan matrix prepared by ionotropic gelation method, the retardation of drug release from chitosan spheroids by microwave required a more complex formulation containing both stearic acid and sodium chloride unless a high stearic acid fraction was used. These spheroids demonstrated a high resistance to disintegration during dissolution owing to salt-induced bridging by sodium chloride. In response to microwave, sodium chloride aided stearic acid spread and effected domain interaction via C=O moiety over a matrix with reduced specific surface area thereby reducing drug dissolution. The drug release of spheroids can be retarded by microwave through promoting the layering of hydrophobic stearic acid in a matrix structure sustained by sodium chloride.
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Citation
Zakaria Zabliza, and Tin Wui Wong, "Chitosan Spheroids with Microwave Modulated Drug Release," PIER, Vol. 99, 355-382, 2009.
doi:10.2528/PIER09101001
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